The whole body JAK2 knockout mice are embryonic lethal 1011therefore, tissue-specific functions of JAK2 have been elucidated with Cre recombinase system. Drafting of manuscript: Cao, Food Funct.
John Krystal, Editor of Biological Psychiatry. Also, EBN showed a dose-dependent effect on the expression of antioxidant genes but not serum total antioxidant status possibly because post-transcriptional modifications produced effects to the same degree irrespective of the degree of transcriptional changes induced.
Wild-type mice were transplanted with either wild-type or P2Y2 receptor null bone marrow and treated with a sublethal dose of endotoxin as a model of acute inflammation, or fed a high-fat diet to induce obesity and insulin resistance as a model of chronic inflammation. The glucose tolerance test was altered in both HFD groups.
Shock 1 Google Scholar 5. Retrieved on May 7,from https: Purinergic Signal 8: Glucose tolerance was assessed and plasma levels of glucose, insulin, leptin and adiponectin were measured at various time points throughout the study.
Four slides from each group were included in high fat diet induced inflammation and 5 fields were randomly selected on each slide. Metabolic activation of macrophages is not limited to adipose tissue, but obesity-induced inflammatory changes have also been reported in liver, muscle, hypothalamus and pancreas 5affirming the significant role of these cells in the physiological response.
There was a reduced expression of macrophage-specific gene Cd68 Fig. Changes in the inflammatory profile were less intense in the cecal lymph nodes and spleen, showing only minor alterations see additional file 2 - Table S2.
Dis Model Mech 3: Interestingly, despite lack of effect of EBN on the expression of the IL6 gene data not shownwe observed a change in its serum levels. Free Radic Biol Med In our study, leptin expression was increased in adipose tissue in both HFD groups compared to the colitis group.
Simvastatin was similarly able to prevent reduction in antioxidant status. In this study, we determined HFD induced development of metabolic disorders on outbred female CD-1 mice in a time dependent manner.
The impact of chronic colitis on adipose tissue inflammation was confirmed by intravital microscopy performed in the adipose tissue microvasculature see additional files 3456 - videos In all cases the Ref.
Polyunsaturated fatty acids n-6 PUFA, also known as linoleic acid LA is thought to be pro-inflammatory and it can be converted into arachidonic acid AA [ 44 ].
The quantity of fat is thought to have greater impact on postprandial inflammatory response in overweight and obese than in healthy lean individuals [ 15 ]. Leptin is produced in adipose tissue in response to fat mass and controls appetite and energy expenditure by hypothalamic pathways [ 36 ].
The results suggest that increased expression of antioxidants through transcriptional regulation may partly underlie the increased antioxidant status in the rats that consumed EBN. Although circulating levels of adiponectin were similar among groups, its expression in adipose tissue was reduced in all groups compared to the control group.
Discussion The role of JAK2 during obesity and insulin resistance appears to be tissue-specific, as demonstrated by genetic ablation in the pancreas, liver and adipose tissue 1213141516 The association of colitis with HFD significantly aggravated these changes, except for goblet cell depletion, which was similar in both groups with colitis Figure 1B-E.
Journal Reference: Nauert began his career as a clinical physical therapist and served as a regional manager for a publicly traded multidisciplinary rehabilitation agency for 12 years. We demonstrate that HFD progressively induced a variety of metabolic disorders, including adiposity, adipocyte hypertrophy, ectopic fat deposition, insulin resistance, hyperinsulinmia, and pancreatic islet hypertrophy, which was associated with elevated expression of genes involved in adipose chronic inflammation and hepatic lipid sequestration.
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